Soft Nanostructures for Patterning Biomolecule Tracks for Molecular Motors
Jay Park, Matthew Caparizzo, Yujie Sun, Yale E. Goldman, and Russell J. Composto
- Soft nanostructures are smart substrates for immobilizing/patterning biomolecules (e.g, .F-actin , proteins).
- Precise control over molecule location and adhesion is essential to molecular motor driven separation, purification and detection devices, and biomolecular micro-electrical, mechanical systems (Bio MEMS).
OBJECTIVE AND APPROACH:
- Control interaction between biomolecule and soft nanostructures using (1) amphiphilic block copolymers (2) hydrophobic block copolymers, (3) charged hydrogels and (4) nanoparticle decorated surfaces.
- Biomolecule attachment to soft nanostructures depends on surface charge, substrate modulus, and nanodomain size.
- Future studies will examine viability of F-actin, attached to nanoparticles, for supporting molecular motor motion.