Stability Enhancement of DNA Nanogrids via Streptavidin-Biotin Complexation

Lei Zhang, Ivan J. Dmochowski

DNA is a versatile building material for nanoconstruction because of its attractive molecular recognition capability and well-predicted duplex conformation. However, these DNA nanostructures are prone to dissociation when solution condition changes, including variation of the buffer media and increase of the temperature. In this contribution, we aim at enhancing the stability of DNA nanostructures via introducing a streptavidin-biotin complexation unit. As a prototypical study, a DNA complex featuring a nanogrid structure is chosen.