Probing the Single Molecule Ligand-Receptor Interaction by Synthetic Molecular Tip

Yoko Yamakoshi

As stable “molecular tips” for AFM tip functionalization, tripod molecules were synthesized for Au surface modification of AFM tip and applied to chemical force spectroscopy for single molecular interaction of model ligand-receptor (biotin-NeutrAvidin). More precise and reproducible value for single molecular unbinding force were obtained from this system. Currently, chemical functionalization of NCD AFM tip and potential application to nano-lithography is going in collaboration with Dr. Carpick group and Dr. Composto group.