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The effect of metalloproteins on the structure of micelles adsorbed on surfaces

Kendra Kathan Galipeau, Ivan Korendovych, Alessandro Senes, William DeGrado and Dawn Bonnell

metalloproteins on the structure of micelles adsorbed on surfaces

Synthetic peptides have been developed to template optically active molecules.  These can be incorporated into micelles to enable nanostructure formation.   It is important to understand how the insertion of a molecule such as a metalloprotein influences micelle aggregation. These experiments examine how the inclusion of a protein complex affects the way in which these structures form on a surface. PRIME was successfully incorporated into micelles in bulk solution, but consequences to behavior on surfaces was previously unknown.

Hemicylindrical stripes form with the addition of PRIME.  The pitch of the stripes in the case of pure micelles is 5.1 nm.  With the addition of PRIME, the pitch increases to 5.5 nm.  This change in pitch may be an indication that PRIME has remained incorporated in the aggregates during assembly on the surface.

 

 

 

 

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