AFM and Multi-Color pol-TIRF Nano-Imaging: Multi-Motor Filament Example
Dennis Discher and Yale Goldman
To obtain structural and mechanical information from biological nano-machines before/during/after adsorption, assembly, dissection, compression, and/or unfolding during cycles of mechano-chemical activity.
Scientific strategy, approach and uniqueness
No one in the world has reported single molecule fluorescence simultaneous with single molecule mechanical probing.