(ONE-HEADED) MYOSIN Ic KINETICS
PIs: M. Arsenault, M. Ostap, Y. E. Goldman , and H. H. Bau
Understanding Myosin motors kinetics is necessary for understanding their function, the design of single molecule experiments, and the design of motor-based devices.
Stopped flow kinetic measurements of one-headed myosin Ic motor bound to actin filament were carried out to determine the ATP-binding rate and the motor’s affinity to ADP.
Slow kinetics (slow dissociation rate)
Strong affinity to ADP