Beta-site for AFM-coupled Single Molecule Fluroescence
Dennis E. Discher and Yale Goldman
Global objectives and specific goals of the project:
The broad goal is to understand how molecules distort under stress by using AFM to push & pull on molecules while monitoring their properties at the level of single fluorophores.
Scientific strategy, approach and uniqueness
No one in the world has ever reported single molecule fluorescence simultaneous with single molecule mechanical probing
References: Law et al, Journal of Biological Chem. 2004