Beta-site for AFM-coupled Single Molecule Fluroescence

Dennis E. Discher and Yale Goldman

Global objectives and specific goals of the project:

The broad goal is to understand how molecules distort under stress by using AFM to push & pull on molecules while monitoring their properties at the level of single fluorophores.

Scientific strategy, approach and uniqueness

No one in the world has ever reported single molecule fluorescence simultaneous with single molecule mechanical probing

References: Law et al, Journal of Biological Chem. 2004