DNA conformational changes Observed via tethered-particle method
Nelson: NBIC and NSF DMR
Objective: develop new, noninvasive methods to visualize DNA conformational changes in real time, in physiological conditions.
Our results open the way to use this method to monitor gene regulatory processes, such as DNA looping, in real time.
References: PC Nelson, D. Brogioli, C. Zurla, D. D. Dunlap, and L. Finzi, submitted to JMB.