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Encapsulation of Novel Optoelectronic Cofactors into Amphiphilic 4-helix Bundle Peptides


J. Kent Blasie & Michael J. Therien

Novel non-biological cofactors are based on p-electron systems that extend throughout the electron donor-bridge-acceptor components of a single cofactor. Such cofactors can possess both novel electronic and optical properties tailored by design. Amphiphilic 4-helix bundle peptides are designed to specifically bind a number of these novel cofactors in a vectorial manner within the bundle. The amphiphilic nature provides for their unique vectorial orientation in the laboratory frame, e.g., at a “soft” interface between polar and non-polar media or on an electrode surface.

Scientific Strategy & Impact:
The work (Blasie) concerns the detailed intra-molecular structures & inter-molecular ordering of the peptide-cofactor complexes on electrode surfaces utilizing the techniques of x-ray & neutron scattering and polarized absorption & emission spectroscopies. This work will provide essential structural information in support of the measurements of single molecule optoelectronic device function.

Ye, S., Discher, B.M., Strzalka, J.W., Xu, T., Wu, S.P., Noy, D., Kuzmenko, I., Gog, T., Therien, M.J., Dutton, P.L. and Blasie, J.K. (2005) Amphiphilic 4-Helix Bundles Designed for Light-Induced Electron Transfer Across Soft Interfaces. Nano Lett. 5(9):1658-1667.




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